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Semax is a heptapeptide, synthetic analogue of an ACTH(4-10) fragment of corticotropin, of the following structure: Met-Glu-His-Phe-Pro-Gly-Pro.
Based on one of the endogenous neuropeptides regulating the functions of the central nervous system, Semax is a nonaddictive nootrop of prolonged action capable of stimulating memory and attention. It is characterized by wide spectrum of prolonged action, and the absence of hormonal activity and side effects. Therapeutic action of Semax after single application starts within 1 hour and lasts as long as 24 to 48 hours. Its effective doses (15-50 (g/kg) are roughly 1000 times smaller than those of widely known nootropil (pyracetame).
Semax stimulates predominantly the functions of the anterior cerebrum. It positively affects the processes underlying perception, analysis of information, training and memory. Semax markedly improves the adaptation of the human organism to stress (hypoxia, cerebral ischemia, etc.). It facilitates recovery of mnestical functions after anesthesia. Semax supports high levels of attention, stimulates memory and facilitates accelerated recovery of intellectual and physical potential. Semax supports active attention and ability to work in conditions of nervous and psychic fatigue like strenuous operator activity. It also accelerates adaptation of the cardiovascular system to increased physical workload. Semax can be used for treatment of intellectual and mnestical disorders, of cerebral vascular diseases, for rehabilitation after craniocerebral traumas, treatment or prevention of post-anesthesia effects as well as for treatment of asthenoneurotic disorders of various geneses including ionizing radiation. Healthy people may take Semax to stimulate their memory and capacity for work, as well as improvement of the mood and neutralization of stress effects.
Semax was tested on operators of the Perm Power Station, and mine rescue workers at the Coal Basin of the Moscow Region (Russia). The results suggest Semax to be potentially used among the following groups of people: operators of atomic and electric power stations, civil and military air traffic controllers, PC users, buisenessmen and officials during negotiations requiring high concentration of attention and memory, drivers and sportsmen.
Semax 0.1% 3 ml (1 vial)
Dosage: nasal drops 0.1%
Description: Colorless clear liquid.
Pharmacotherapeutic group: Nootropic drugs.
ATC code - [N06BX]
Pharmacological propertie: Semax nasal drops 1% - The original synthetic peptide preparation, which is the analogue of a fragment of adrenocorticotropic hormone (AKTG4-10) (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline) is completely devoid of hormonal activity. All the amino acids are L-shaped.
Pharmacodynamics: Semax has an original mechanism neurospecific action on the central nervous system (CNS). The drug affects the processes associated with memory formation and learning. Semax enhances attention in training and analysis of information, improves the consolidation of the memory trace, improves adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences. The drug is practically non-toxic in single and prolonged use. Shows no allergic, embryotoxic, teratogenic and mutagenic properties. Has no local irritating action.
Pharmacokinetics. Absorbed from the mucosa of the nasal cavity, while digested to 60-70% in percenatge of active substance. Semax is quickly delivered to all organs and tissues, crosses the blood-brain barrier. When being injected into the blood, Semax undergoes fairly rapid degradation and removal from the body with urine.
Indications for use: Acute ischemic stroke.
Contraindications: Hypersensitivity to the drug. Acute mental status disorder, accompanied by anxiety, pregnancy, lactation, history of convulsions.
Side effects: Prolonged use may cause mild irritation of the nasal mucosa.
Semax applied intranasally, using a bottle sealed with a plastic cap-dropper.
Carefully cut off the tip of the pipette.
The cap should be tightly closed dropper - Fig. 2.
Turn the bottle and easily tap the bottom, wait for the liquid filled the entire space of pipette.
Remove the cap and a create light pressure on the wide part of the pipette, squeeze the required number of drops of the drug in the nasal passage.
Drug should be stored with tightly closed cap.
The volume of one drop equals to 0.05 ml (50 ml). One drop of standard solution contains 500 mg of active ingredient.
Release form: 3 ml vial, sealed with a plastic cap-dropper. Each vial with instructions for use.
Storage condition: in darkness, at a temperature not exceeding +10 ° C, avoid freezing. Keep out of reach of children.